June 21, 2017 By danablog505 in Books, Dana Alliance for Brain Initiatives, Neuroeducation Tags: A Day in the Life of the Brain, anxious, Behave The Biology of Humans at Our Best and Worst, Cerebrum, DABI, Dana Alliance, Elena Cattaneo, Gordon Shepherd, Joseph LeDoux, Kay Redfield Jamison, Mark Schatzker, Neuroenology: How the Brain Creates the Taste of Wine, New York Times, NPR, Patricia Bosworth, Robert Lowell Setting the River on Fire, Robert Sapolsky, Summer Reading, Susan Greenfield
A team of neuroscientists and engineers are working to develop a new form of treatment for people who have Parkinson’s disease, depression, or obsessive-compulsive disorder. According to a recent New York Times article, the available methods for treating these conditions currently involve the risks of surgery and can have limited ability with directing electrical pulses to the right areas of the brain.
Dana Alliance member Helen Mayberg, tells the Times:
They have this clever new way to deliver current[s] to a spot of interest deep in the brain and do it without invading the brain…If you didn’t have to actually open up somebody’s brain and put something in it, if it could do what we’re doing now just as well—sign me up.
So far the research has only been conducted in mice, but experts are hoping the technique will work for people, too. “This is something that many of us in the field have wished for for a long time,” says Alexander Rotenberg. Rotenberg is director of the neuromodulation program at Boston Children’s Hospital and Harvard Medical School. The article goes on to explain the details of the non-invasive treatment:
The method, called temporal interference, involves beaming different electric frequencies, too high for neurons to respond to, from electrodes on the skull’s surface. The team found that where the currents intersected inside the brain, the frequencies interfered with each other, essentially canceling out all but the difference between them and leaving a low-frequency current that neurons in that location responded to.
For more information on the experimental study, read the full article here.
– Seimi Rurup
Early world explorers worked with crude maps, painfully charting the geography of new locations for future generations. Today, anyone can log on to the internet for detailed descriptions of the countries, cities, and roads of our world. In comparison, the map of the brain still has a long way to go. In fact, a map of the brain made over 100 years ago is still being used by neuroscientists today.
“Cartographers of the Brain: Mapping the Connectome,” a discussion at the World Science Festival in New York City, focused on efforts by neuroscientists to create new, more detailed maps of the brain. Deanna Barch, Washington University School of Medicine; Nim Tottenham, Columbia University; Dana Alliance member Jeff Lichtman, Harvard University; and Dana Alliance member David Van Essen, Washington University, formed the expert panel.
What if life expectancy expanded and we could live into our nineties and beyond in relative good health? That was one of the crucial questions debated in “Engineering Immortality,” a panel discussion at last week’s World Science Festival in New York City.
In introducing the sold-out program at NYU’s Global Center, host and ABC-TV news correspondent Bill Blakemore pointed out that American life expectancy has gone from 47 to 79 years in just a century. “Today’s scientists are growing hearts in the lab, creating organs with 3-D bio-printers, and eliminating cells that shorten life,” he said. “Will this new technology yield another dramatic increase in life expectancy?”
A New York Times profile earlier this week on Brenda A. Milner, Sc.D., credited her with changing “the course of brain science for good as a newly minted Ph.D. in the 1950s by identifying the specific brain organ that is crucial to memory formation.”
Milner, a Dana Alliance for Brain Initiatives member, identified the hippocampus and other areas of the brain that process memory while working with Henry Molaison, more commonly known as H.M., who developed amnesia at age 29 from the removal of tissue from both his medial temporal lobes, a surgery that was supposed to alleviate his epilepsy.
With the help of H.M., Milner discovered that memory was processed in the medial temporal lobes, which was why he could no longer form new long-term memories. He was, however, able to learn new tasks, meaning he must remember the actions in another part of the brain. His ability to acquire new skills proved to Milner there are two types of memory that occur in different parts of the brain – explicit memory, which recalls describable details like facts and events, and implicit memory, for unconscious memories such as actions and procedures. Milner described this finding in a 2010 Dana Foundation interview:
I went to the McGill psychology department and borrowed learning tasks to give him [H.M]. I took down a maze task, which I was sure he wouldn’t learn, and he didn’t. It was a nice control test, because he showed absolutely no progress over three days. Then I gave him the mirror drawing task. H.M. did 30 trials over three days and at the end of the last trial, his performance was absolutely perfect. I can still remember him looking at what he had drawn, saying: “This is strange. I thought this would be difficult, but it looks as though I’ve done it rather well.” I was very excited because it showed that he could have this excellent performance without any awareness that the reason he was doing so well was that he had had the chance to practice the task over three days.
When I saw that H.M. had this beautiful learning of something he had no memory of having acquired, I then speculated that this task, which involved motor learning, depended on a different system in the brain. His surgeon had damaged his medial temporal system, but this was a kind of learning that was unaffected by this operation, so therefore it must involve other structures.