Glossary of Brain Science Terms

Do you enjoy reading about the brain, but occasionally run into a neuroscience term you don’t know or that sounds familiar, but you just can’t quite put your finger on its meaning? The Dana Foundation’s Glossary of Key Brain Science Terms is a handy companion for those instances.

brain_glossary_cover_imgWant to know the difference between explicit and implicit memory? We’ve got you covered. Aren’t quite sure what brain plasticity means? We offer a concise explanation.

The Glossary has more than 150 defined terms and can be bookmarked on your computer for easy reference or printed to have on hand.

We hope you find it useful!

CRISPR Beyond Gene-Edited Babies

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Photo credit: Shutterstock

In late November, it was hard to miss the shocking claim that a Chinese researcher used CRISPR, a relatively new gene-editing technique, on twin baby girls while in the embryonic state. According to the Associated Press, the researcher, He Jiankui, said his goal “was not to cure or prevent an inherited disease, but to try to bestow a trait that few people naturally have—an ability to resist possible future infection with HIV, the virus that causes AIDS.”

The procedure was quickly denounced by many scientists as unsafe and unethical, with the potential to harm not only the girls’ genes, but also their offspring. Many articles on the subject followed, debating the ethics and safety of the work. Adding to the controversy is that the research has yet to be verified in a peer-reviewed journal.

But how did we get here? What is CRISPR and its intended use? For people who want a little more background on this groundbreaking technique, and its importance beyond the latest headlines, we invite you read our new briefing paper on CRISPR and its use in neuroscience—both as a research tool and, potentially, a treatment for brain-related disorders.

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Series Combats Disorders: First Up, Epilepsy

caveat logo.JPGPeople with epilepsy were once thought to be possessed by demons or evil spirits. Dubbed “the sacred disease,” epilepsy was profoundly misunderstood for centuries, even after the disorder was explained to be of human origin. So why is it, so many years later, that epilepsy is still not fully understood? And why is there still so much stigma attached to a disorder which affects approximately one in 26 people in the United States?

Caveat NYC, BraiNY, and the Epilepsy Foundation are attempting to eliminate that stigma. Last week saw the first part of a three-part event series, titled “A Lot On The Mind: Epilepsy.” Held at Caveat at 21 A Clinton St. in Manhattan and open to the public, tickets are $15 each. Each event in the series is hosted by Stephanie Rogers, a Ph.D. candidate at New York University and an adjunct instructor at Fordham University. The series focuses on educating and demystifying misconceptions on epilepsy, autism, and Huntington’s Disease.

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Stephanie Rogers. Photo: Caveat NYC

Rogers, whose sister suffers from untreatable epilepsy, began by showing slides that explained the origins and causes of epilepsy. They include brain infection, head trauma, brain tumor, and stroke, as well as a genetic link. However, as Rogers explained, the cause of epileptic seizures remains a mystery in many patients. Continue reading

From the Archives: Rita Levi-Montalcini

Levi-Montalcini_featDana Alliance member Piergiorgio Strata has just published “Rita Levi-Montalcini and her major contribution to neurobiology” in Rendiconti Lincei; its English version is open-access for reading via Springer Publishing. Its 17 pages are filled with family and science-family photos, including as she entered medical school and when she was awarded a Nobel Prize, and her major scientific collaborators, as well as classic illustrations of her work in neuroembryology and much more (she lived to age 103). Her personal story is inspiring—including doing seminal research at home during wartime in Italy after she was banned from entering formal research facilities because of her faith.

“Life does not end with death. What you pass on to others remains. Immortality is not the body, which will one day die. That does not matter… of importance is the message you leave to others,” said Levi-Montalcini, who was also a founding European Dana Alliance for the Brain member. We were working with her to publish a translation of her latest memoir into English when she died, in 2012. Continue reading

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