“Since the 1960s, billions of dollars and probably millions of animals have gone into the search for new and better anti-anxiety medications,” said researcher Joseph LeDoux at an event this week on anxiety at the American Association for the Advancement of Science. But drug makers, who have spent years targeting points along a brain pathway described as the “fear circuit” in animals, haven’t had the success they sought; they have stopped funding many studies. Why?
LeDoux, a Dana Alliance member at New York University who has studied this circuit for the past three decades, argues that the term we use may have blinded us to what the circuit actually does. Instead of labeling it with a human feeling, it would better to call it an unconscious “defensive survival circuit.” Other inputs lead to the conscious feelings of fear and anxiety. For example, while hiking, we have already recoiled from the snake on the trail before our conscious minds have hit the danger signal. The two things happen so fast, though, it’s easy to think the feeling led to the action—but we’re committing the first sin of science: confusing correlation and causation, LeDoux said.
From left: moderator Mark Frankel, Joseph LeDoux, and Daniel Pine field questions from the audience.