Autism is a mysterious and puzzling disorder. In 1943, American child psychiatrist Leo Kanner first published a paper describing 11 children who were highly intelligent but displayed “a powerful desire for aloneness” and “an obsessive insistence on persistent sameness.” He called this condition “early infantile autism.” Prior to that time, people with autism were simply called insane. Autism is now officially known as autism spectrum disorder (ASD) and, while there is a wide variation in the nature and severity of its signs, people with ASD typically have difficulty with social communication and interaction, restricted interests, and repetitive behaviors. Continue reading
On the latest episode of the Clear + Vivid podcast, host Alan Alda, well-known actor, writer, and, in recent years, crusader of science outreach, sits down with old friend and Dana Alliance for Brain Initiatives member Eric R. Kandel, director of the Kavli Institute for Brain Science at Columbia University and author of The Disordered Mind: What Unusual Brains Tell Us About Ourselves. Kandel speaks to Alda about his work, the satisfaction of connecting with audiences, and fleeing Austria in the aftermath of its annexation to Nazi Germany.
The podcast focuses on communication and connection. It’s through conversations with individuals holding mastery in various fields that Alda guides the listener, stopping to appreciate peaks and valleys of the art form. In this, Alda and Nobel Laureate Kandel find and sustain a relaxed stride, offering listeners morsels of wisdom: The importance of being mindful of your audience, focusing on one person and changing your approach based on their responses (favorable or not); the role of laughter in forming connections; and the delicate dance of simplifying your ideas to a lay audience without treading on and distorting the science. Continue reading
We regret to announce the loss of Dana Alliance member Arvid Carlsson, M.D., Ph.D., who passed away last Friday at 95 years old. Carlsson laid the groundwork for the treatment of Parkinson’s disease by discovering dopamine is a neurotransmitter that plays an important role in motor function. In 2000, this research won him the Nobel Prize in Physiology or Medicine with fellow Dana Alliance members Eric R. Kandel, M.D., and Paul Greengard, Ph.D., “for their discoveries concerning signal transduction in the nervous system.”
In 2001, Dana Alliance member John H. Byrne, Ph.D., wrote a Dana Foundation Cerebrum article to commemorate the 2000 Nobel Prize in Physiology or Medicine. He detailed Carlsson’s journey to his Nobel Prize winning research on dopamine:
As neuroscience enthusiasts already know, there are countless podcasts out there about brain-related topics. To inform my Cerebrum podcasts, I’ve sampled many of them to pick up tips on how to explain research that can often be complex and difficult to understand.
One such podcast that does a masterful job of explaining both chronic traumatic encephalopathy (CTE) and false memory is Revisionist History, a podcast by Malcolm Gladwell, a former New Yorker staff writer and the author of Tipping Point, Blink, and other New York Times best seller nonfiction works. The podcast labels itself as a “journey through the overlooked and misunderstood.”
The CTE episode, entitled “Burden of Proof,” focuses on Owen Thomas, a captain of the University of Pennsylvania football team who committed suicide several years ago. Gladwell builds the episode from a talk on the topic of “proof” that he gave to students at Penn in 2013. He used CTE, a neurodegenerative disease found in people who have had multiple head injuries, to make his point.
Nearly 45,000 people in the US kill themselves each year (probably an underestimate, given the stigma still attaching to suicide), and there may be 25 attempts for each death, according to the US Centers for Disease Control & Prevention. A news story we published in January reported on a few of the many avenues of research trying to help doctors and caregivers predict who is at risk and how to better help them.
“Suicide is one of the few medical conditions in which the doctor and patient have different goals—the patient may be highly motivated not to reveal what he or she is thinking,” psychiatrist Maria Oquendo says in the story. “We need biological markers so we can identify those at risk.”