In Memoriam: Nobel Laureate Arvid Carlsson, a Pioneer in Parkinson’s Treatment

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Photo: Johan Wingborg/University of Gothenburg

We regret to announce the loss of Dana Alliance member Arvid Carlsson, M.D., Ph.D., who passed away last Friday at 95 years old. Carlsson laid the groundwork for the treatment of Parkinson’s disease by discovering dopamine is a neurotransmitter that plays an important role in motor function. In 2000, this research won him the Nobel Prize in Physiology or Medicine with fellow Dana Alliance members Eric R. Kandel, M.D., and Paul Greengard, Ph.D., “for their discoveries concerning signal transduction in the nervous system.”

In 2001, Dana Alliance member John H. Byrne, Ph.D., wrote a Dana Foundation Cerebrum article to commemorate the 2000 Nobel Prize in Physiology or Medicine. He detailed Carlsson’s journey to his Nobel Prize winning research on dopamine:

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From the Archives: Circadian Rhythms

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Image: Shutterstock

This year’s Nobel Prize in Physiology and Medicine was awarded to three men who did basic research, discovering molecular mechanisms that control the circadian rhythm. The discoveries by Jeffrey C. Hall, Michael Rosbash and Michael W. Young “explain how plants, animals and humans adapt their biological rhythm so that it is synchronized with the Earth’s revolutions,” write the Nobel committee.

They and other researchers have continued to add details to our understanding of this critical system. In a story for Cerebrum in 2014, Paolo Sassone-Corsi described two relatively new areas of research: circadian genomics and epigenomics:

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Science Meets Art in New Kandel Book

Creativity (2).jpgWe don’t typically think of science and art as rooted in similar methodologies or techniques. Science is considered a strict, fact-based study of the world around us, while art is a no-rules expression of creativity. By thinking of the two disciplines as distinctly different, there has not been much study of their similarities.

Dana Alliance member Eric R. Kandel, M.D., noticed the lack of interdisciplinary study of artistic and scientific methodologies and used it as the foundation for his new book, Reductionism in Art and Brain Science: Bridging the Two Cultures. The book examines modern neuroscience alongside modern art, focusing on how both disciplines use reductive techniques. In a recent interview with the Wall Street Journal about his book, Kandel said:

This is reductionism—to take a complex problem and select a central, but limited, component that you can study in depth. Rothko—only color. And yet the power it conveys is fantastic. Jackson Pollock got rid of all form.

[In neuroscience] you have to look at how behavior is changed by environmental experience…I began to realize we’ve got to find a very simple learning situation…I looked around for an animal that had the kind of [simple] nervous system I would like. Aplysia [has] the largest nerve cells in the animal kingdom.

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From the Archives: Funding Scientific Research

Leon Cooper in 2007. Photo by Kenneth C. Zirkel

Leon Cooper in 2007. Photo by Kenneth C. Zirkel

More than 16 years ago, Cerebrum published an essay by Leon Cooper, Nobel prize-winning physicist and a member of the executive committee of the Dana Alliance for Brain Initiatives, on the monetary state of the field then, called “Scientific Research: Who Benefits? Who Pays?” Has anything changed?

In 1998, the annual direct and indirect costs of brain-related illnesses in the U.S. was estimated at $600 billion, writes Cooper. The figure now is $760 billion; worldwide, the WHO has estimated costs at $3 trillion and increasing. Continue reading

From the Archives: How Neuroscience Captured the 21st Century

When researchers Arvid Carlsson, Paul Greengard, and Eric Kandel shared the Nobel Prize in Physiology or Medicine in 2000, we commissioned memory researcher John H. Byrne to write an essay on what their achievements meant to the field. In his 2001 essay, “How Neuroscience Captured the Twenty-First Century’s First Nobel Prize,” Byrne starts with a good chunk of Kandel’s acceptance speech; gives a cogent review of each scientist’s separate path and how their discoveries eventually entwined; describes how this changed the field; and considers what it might mean for the future. As you might suspect, it’s a long essay, but full of gems.

Whether overdue or just in the nick of time (as the Decade of the Brain closes), this Nobel Prize celebrates an achievement different in kind from previous observation, speculation, and investigation of the brain. For the first time, an unambiguously mental phenomenon—memory—has been explained in wholly material, mechanical terms. The hypothesis of a separate, nonmaterial, otherworldly realm has become superfluous. A banquet is not the place to spin out these disturbing implications, but Kandel does acknowledge them, for those who will hear, by returning to where his story began—“Know thyself.”

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