From the Archives: Patient H.M.

Four years ago, many of us sat transfixed watching a web videostream as the frozen brain of one of the most famous amnesiac patients in history was dissected, slice by slice. The plan was to image these ultrathin slices and put them into a public database all researchers could see. This week, the database was released along with a paper in Nature Communications on what researchers Suzanne Corkin, a DABI member, Jacopo Annese, and their colleagues found.

(a,b) Lesions in the deep WM were visible in postmortem T1-weighted MRI images acquired ex situ (scale bar, 1 cm) and were confirmed by myelin silver-impregnation40, 46 (c) and haematoxylin and eosin (H&E) staining (d). Scale bar, 5 mm.

(a,b) Lesions in the deep WM were visible in postmortem T1-weighted MRI images acquired ex situ (scale bar, 1 cm) and were confirmed by myelin silver-impregnation40, 46 (c) and haematoxylin and eosin (H&E) staining (d). Scale bar, 5 mm.

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Brenda Milner Wins the 2011 Pearl Meister Greengard Prize

Today, Dana Alliance Member Brenda Milner, Ph.D., will be awarded the 2011 Pearl Meister Greengard Prize for her contributions to the field of cognitive neuroscience.

Many past Dana publications highlight Dr. Milner’s work with Patient H.M., now known to be Henry Gustav Molaison—the focus of this month’s “From the Archives” feature. Milner

In 1953, Mr. Molaison underwent surgery that removed two-thirds of his hippocampus—the part of the brain responsible for memory formation and storage—along with several other structures involved with emotions and memory, in an attempt to control his severe epilepsy.

The surgery successfully alleviated Mr. Molaison’s seizures. But it also left him without the ability to form new memories. Dr. Milner began working with him in 1955. In an interview from March 2010, she described her early experiences:

I gave him standard intelligence tests and memory tests . . . and I would talk to him, distract him and give him numbers to remember and so on. H.M. (Henry Molaison) could pay attention and had no problem with immediate memory, but as soon as he was distracted, he would forget what had happened before. So you could make this general prediction [about H.M.] that he’s going to forget everything, but no psychologist is happy with this sort of statement—you can’t test a null hypothesis. The challenge was: with practice, with repetition, could he learn something?

I went to the McGill psychology department and borrowed learning tasks to give him. I took down a maze task, which I was sure he wouldn’t learn, and he didn’t. It was a nice control test, because he showed absolutely no progress over three days. Then I gave him the mirror drawing task. H.M. did 30 trials over three days and at the end of the last trial, his performance was absolutely perfect. I can still remember him looking at what he had drawn, saying: “This is strange. I thought this would be difficult, but it looks as though I’ve done it rather well.” I was very excited because it showed that he could have this excellent performance without any awareness that the reason he was doing so well was that he had had the chance to practice the task over three days.

When I saw that H.M. had this beautiful learning of something he had no memory of having acquired, I then speculated that this task, which involved motor learning, depended on a different system in the brain. His surgeon had damaged his medial temporal system, but this was a kind of learning that was unaffected by this operation, so therefore it must involve other structures.

In 2007, a Gray Matters radio segment featured her work with Mr. Molaison—you can listen to or read a transcript of the segment, which includes the voices of both Dr. Milner and Mr. Molaison.

Following Mr. Molaison’s death in 2008, the Dana Foundation partially funded the dissection and digital preservation of his brain.

–Johanna Goldberg

(Photo credit: Owen Egan; courtesy of the Montreal Neurological Institute, McGill University)

H.M. brain dissection live online

The brain of Henry Molaison, the most famous amnesic and perhaps the most-studied neurological patient in history, will go under the knife starting Wednesday morning. Mr. Molaison, who died in February, donated his brain to science; as part of the Brain Observatory Project, his contribution will help thousands of researchers worldwide.

Brain Project scientists plan to Webcast the slicing and preservation of brain matter on thousands of slides; extra-high-resolution digital images of the slides will eventually be posted on the open-access site. The operation is scheduled to start Wednesday mid-morning and may take up to 30 hours. Part of this project is supported by a grant from the Dana Foundation.

On Monday, the San Diego Union-Tribune published a nice explanatory story on Mr. Molaison and the work of the Brain Project, which is based at the University of California, San Diego. I also wrote a short piece (with an audio link) about him for Dana’s 2008 annual report.


 

—Nicky Penttila

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